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HER2 FISH
Synonyms: HER-2 fluorescence in situ hybridization
Application: HER-2 gene amplification in formalin fixed, paraffin embedded tissues, usually human breast tissue. HER-2 FISH results correlated with clinical and pathological information can be used as a prognostic tool for stage II, node positive breast.
Specimen Type: Formalin-fixed, paraffin-embedded tissue blocks (FFPE). If tissue blocks are not available, unstained slides are acceptable (please submit 1-2 slides per antibody to be tested, cuts must be 4 microns thick).
Collection Procedure: Tissue removed during a surgical procedure and placed in 10% NBF soon after removal from the patient. Appropriate tissue for requested staining.
Required Info: Patient's full name, DOB, Soc Sec #, Date of specimen collection, Ordering MD
Specimen Stability: Ambient: Indefinite as paraffin block; 6 weeks for recut slides
Unacceptable Specimen: Slides or paraffin blocks with no tissue remaining. Samples fixed in fixatives other than 10% neutral buffered formalin. Paraffin blocks that have been overheated or frozen.
Department: Histology
Method: Abbott/Vysis, immunofluorescence, DNA probes
Turn Around: 24-72 hours
Performed: Mon-Fri
Retention: Blocks -10 years; H&E and IHC Slides - 10 years; IF Slides - 30 days
CPT Code: 88368 x2 (The listed CPT codes are for reference use only. These codes should not direct billing practices and may not accurately reflect current billing practices.)

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