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ALL Adult FISH Panel (Acute lymphoblastic leukemia)

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Updated Test Information:

Test Description
ALL Adult FISH Panel (Acute lymphoblastic leukemia)
Synonym(s)

ALL, LBL
General Information

Probes: MYC (8q24), MLL  (11q23), BCR/ABL1/ASS1 t(9:22), ETV6/RUNX1 t(12:21) (probes may be ordered separately)


Disease(s): Acute lymphoblastic (lymphocytic leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), adult
Specimen Requirements

Bone Marrow Aspirate and Peripheral Blood
2-5 mL Sodium Heparin tube (preferred)
EDTA tube (acceptable)
Fixed-cell pellet from cytogenetic analysis slides with metaphase and/or interphase nuclei. (If sending slides please send at least 6 slides for testing)
Additional Processing Details

Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat or freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen
Required Information

Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report
Unacceptable Specimen Conditions

Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens.
Department (code)

FISH
Methodology

Fluorescence in-Situ Hybridization (FISH)
Estimated TAT

3-5 working days from receipt
Testing Schedule

Monday-Friday
Retention

7 days after release of final report
CPT Code(s)

88377x4 manual
Additional Information

Clinical Significance: The adult ALL FISH panel is used for the detection of recurrent chromosome abnormalities observed in adults with ALL of B-cell lineage and B lymphoblastic lymphoma (LBL).

If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. if only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies