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Insulin-Like Growth Factor-1, LC-MS, Serum

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Updated Test Information:

Test Description
Insulin-Like Growth Factor-1, LC-MS, Serum
Synonym(s)

IGF-1; IGF1; Insulin Like Growth Factor I; Somatomedin-C; IGF (Insulin-Like Growth Factor)
Test ID
IGFMS
General Information

Useful for:



  • Evaluation of growth disorders

  • Evaluation of growth hormone deficiency or excess in children and adults

  • Monitoring of recombinant human growth hormone treatment

  • Follow-up of individuals with acromegaly and gigantism
Specimen Type

Serum
Specimen Requirements

  • Preferred: Red Top

  • Acceptable: Serum Gel (SST)
Minimum Sample Volume

0.3 mL
Required Information

Indicate patient's age and sex
Stability

  • Frozen (preferred): 14 days

  • Refrigerated: 72 hours

  • Ambient: 72 hours
Unacceptable Specimen Conditions

  • Gross hemolysis
Methodology

Liquid Chromatography-Mass Spectrometry (LC/MS)
Estimated TAT

2-3 days
Testing Schedule

Monday-Friday
Retention

3 months
CPT Code(s)

84305
Reference Range
Age (years) Males (ng/mL) Females (ng/mL) Age (years) Males (ng/mL) Females (ng/mL)
< 1 18 - 156 14 - 192 17 107 - 615 149 - 509
1 14 - 203 23 - 243 18 - 22 91 - 442 85 - 370
2 16 - 222 28 - 256 23 - 25 66 - 346 73 - 320
3 22 - 229 31 - 249 26 - 30 60 - 329 66 - 303
4 30 - 236 33 - 237 31 - 35 54 - 310 59 - 279
5 39 - 250 36 - 234 36 - 40 48 - 292 54 - 258
6 47 - 275 39 - 246 41 - 45 44 - 275 49 - 240
7 54 - 312 44 - 279 46 - 50 40 - 259 44 - 227
8 61 - 356 51 - 334 51 - 55 37 - 245 40 - 217
9 67 - 405 61 - 408 56 - 60 34 - 232 37 - 208
10 73 - 456 73 - 495 61 - 65 33 - 220 35 - 201
11 79 - 506 88 - 585 66 - 70 32 - 209 34 - 194
12 84 - 551 104 - 665 71 - 75 32 - 200 34 - 187
13 90 - 589 120 - 719 76 - 80 33 - 192 34 - 182
14 95 - 618 136 - 729 81 - 85 33 - 185 34 - 177
15 99 - 633 147 - 691 86 - 90 33 - 179 33 - 175
16 104 - 633 153 - 611 ≥ 90 32 - 173 25 - 179

 

Tanner Stage Males (ng/mL) Females (ng/mL)
Stage I 81 - 255 86 - 323
Stage II 106 - 432 118 - 451
Stage III 245 - 511 258 - 529
Stage IV 223 - 578 224 - 586
Stage V 227 - 518 188 - 512

Note: Puberty onset, ie, the transition from Tanner stage I (prepubertal) to Tanner stage II (early pubertal), occurs for girls at a median age of 10.5 (+/-2) years and for boys at a median age of 11.5 (+/-2) years. There is evidence that it may occur up to 1 year earlier in obese girls and in African-American girls. By contrast, for boys there is no definite proven relationship between puberty onset and body weight or ethnic origin. Progression through Tanner stages is variable. Tanner stage V (young adult) should be reached by age 18.
Performing Lab

Mayo
LOINC Code(s)

2484-4, 73561-3
Additional Information