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Lupus Anticoagulant with Interpretation

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Updated Test Information:

Test Description
Lupus Anticoagulant with Interpretation
Synonym(s)

Dilute Russell Venom time, DRVVT, LAC, LUPINH, Lupus Inhibitor, UOW5250, Hexagonal Phospholipid Neutralization, HEXLA, HEXPL
Test ID
LUPI2
General Information

Lupus inhibitor or Lupus anticoagulant (LA) interferes with phospholipid-dependent coagulation assays. Lupus inhibitors are associated with thrombocytopenia, arterial and venous thrombosis, and recurrent fetal loss. The Hexagonal Phase Phospholipid Lupus Anticoagulant assay (HEXLA) is designed for the qualitative detection of Lupus Anticoagulant (LA) in plasma using hexagonal phase phospholipid and LA sensitive APTT reagent. This HEXLA assay is an integrated (screen and confirm) assay for detection of Lupus Anticoagulant. The delta correction of equal to or greater than 6 seconds is determined to be positive for Lupus Inhibitor.


When clinically indicated, Lupus Anticoagulant, DRVVT (LUPAC) will be reflexively added for diagnosis with an additional charge.


NOTE: Results will be reviewed/Interpreted by an MD and a professional fee is billed.
Container Type

3 mL or 5 mL Light Blue Citrate Tube
Specimen Type

Plasma
Specimen Requirements

Laboratory must process the blue top tubes, within 4 hours of blood collection.
Specimen Collection / Processing Instructions

MUST PROCESS WITH 4 HOURS OF COLLECTION
Platelet poor Coag Citrate Specimen processing:
1. Gently invert tube 2-3 times prior to placing in Centrifuge
2. Centrifuge Citrate whole blood at 4500 rpm for 10 minutes
3. Carefully pipette plasma, avoiding the platelet/buffy coat into a plastic vial
4. Centrifuge plasma at 4500 rpm for 10 minutes
5. Pipette the plasma to a plastic vial, leaving the bottom 0.25 mL undisturbed
6. Freeze plasma immediately and transport frozen. 
Minimum Sample Volume

1 mL
Limitations

This assay is insensitive to heparin levels up to 2 IU/mL. Dabigatran, direct factor Xa inhibitors (rivaroxaban, apixaban), fondaparinux and warfarin do not interfere with the interpretation of this assay. C-reactive protein/acute phase response does not interfere with the interpretation of this assay.
Department (code)

Coagulation
Methodology

Clottable
Testing Schedule

Monday, Thursday
Test Includes

INT1                Coagulation Interpretation
HEXPLP        Lupus Anticoagulant Panel, HEXPL and HEXLA Lupus Anticoagulant, HEXPL
PROLUP       Prothrombin Time, Coag Study
PTTLUP         APTT, Coag Study
TTLUP            Thrombin Time, Coag Study
FIBLUP          Fibrinogen, Coag Study
CPT Code(s)

85384, 85390, 85610, , 85670, 85730, 85598
STAT Orderable (Y/N)

No
Performing Lab

UW
LOINC Code(s)
Collection File View/Download File