Sjogren's Syndrome

Anti-SSB/La, Anti-SSA/Ro, SSA, SSB, SSAB

The presence of both SS-A/Ro and SS-B/La antibodies are highly specific serological markers for the diagnosis and disease management of patients with Sjögren’s syndrome or lupus patients with Sjögren's overlap syndrome. SS-A/Ro antibodies can be a marker for SLE and Sjögren’s syndrome. SS-B/La antibodies are highly specific clinical markers for Sjögren’s syndrome, but a small proportion of patients can remain SS-B/La negative. Assay results should be used in conjunction with clinical findings and other serological tests.

Serum

Tiger

SST

Allow serum tubes to clot for a minimum of 30 minutes before centrifuging. Centrifuge within 1 hour of collection and no longer than 2 hours after collection. Failure to separate red cells from serum with 2 hours of collection may lead to inaccurate results.

1.0 mL

Caution: Serum samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.

Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 2 weeks
If assays are not completed within 2 weeks or the specimen is to be stored beyond 2 weeks, the serum/plasma should be frozen at or below -20˚C.

Plasma, lipemic, hemolyzed or microbially contaminated samples.

Fluorescent enzyme immunoassay (FEIA)

2-5 days

Monday-Friday, alternating days

SS-A/Ro
SS-B/La

86235x2

Incyte Diagnostics

33610-7, 33613-1