Laboratory Services
Small B-Cell Lymphoma (LBCL), Low Grade
Print this pageUpdated Test Information:
| Test Description |
Small B-Cell Lymphoma (LBCL), Low Grade
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|---|---|---|
| Synonym(s) |
SBCL, Low Grade B-Cell Lymphoma, NHL, MCL. MZL. MALT, Follicular lymphoma |
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| General Information |
Probes: BCL6 (3q27.3q28), BCL2 (18q21.33), IGH (14q32.33)/CCND1(11q13.3), MALT1 (18q21.31q21.32) (probe sets may be ordered separately) Disease(s): NHL, B-Cell lymphoma, Mantle Cell lymphoma (MCL), Follicular Lymphoma, Marginal zone lymphoma (MZL), MALT lymphoma |
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| Specimen Requirements |
Bone Marrow Aspirate and Peripheral Blood Formalin fixed paraffin embedded (FFPE) tissue blocks or Fixed-cell pellet from cytogenetic analysis slides with metaphase and/or interphase nuclei. (If sending slides please send at least 6 slides for testing) |
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| Additional Processing Details |
Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat or freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen |
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| Required Information |
Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report. |
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| Unacceptable Specimen Conditions |
Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens. |
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| Department (code) |
FISH |
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| Methodology |
Fluorescence in-Situ Hybridization (FISH) |
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| Estimated TAT |
Heme samples: 3-5 working days from receipt FFPE samples: 4-7 working days from receipt |
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| Testing Schedule |
Monday-Friday |
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| Retention |
Heme samples: 7 days after release of final report FFPE Samples: |
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| CPT Code(s) |
88377x4 manual |
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| Performing Lab |
Incyte Diagnostics |
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| Additional Information |
Clinical Significance: This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas. BCL6 evaluation can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma. Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. If only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies |
