Laboratory Services
Tissue Transglutaminase (tTG) Antibody, IgG
Print this pageUpdated Test Information:
Test Description |
Tissue Transglutaminase (tTG) Antibody, IgG
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Synonym(s) |
tTG, Celiac |
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Test ID |
TTGG
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General Information |
Tissue transglutaminase (tTG) has been identified as the major autoantigen in celiac disease and dermatitis herpetiformis. tTG IgG antibodies are less disease specific but can be useful markers in patients with IgA deficiency. Assay results should be used in conjunction with clinical findings and other serological tests. Antibodies directed against gliadin, its deamidated products, and tTG are dependent on the ingestion of gluten. For this reason, serology testing is best performed in patients on a gluten-containing diet. In children younger than 2 years, it is recommended to combine tissue transglutaminase (tTG) testing with deamidated gliadin (DGP) IgA and IgG. |
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Specimen Type |
Serum |
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Alternate Specimen Type |
Plasma (EDTA or Citrate) |
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Specimen Requirements |
Tiger |
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Minimum Sample Volume |
1 mL |
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Pediatric Min. Volume (if applicable) |
500 uL |
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Additional Processing Details |
Heparin interferes with the measurement of tTG antibodies. |
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Stability |
Stored at 22˚C: 8 hrs |
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Unacceptable Specimen Conditions |
Li-Heparin, lipemic, hemolyzed or microbially contaminated samples. |
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Limitations |
In children younger than 2 years, it is recommended to combine tissue transglutaminase (tTG) testing with deamidated gliadin (DGP) IgA and IgG. |
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Methodology |
Fluorescent enzyme immunoassay (FEIA) |
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Estimated TAT |
2-5 days |
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Testing Schedule |
Monday-Saturday, alternating days |
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CPT Code(s) |
86364 |
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Reference Range |
Negative < 7 U/mL |
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Performing Lab |
Incyte Diagnostics |
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LOINC Code(s) |
56537-4 |